Forensic Psychiatry 
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  1. Mark Levy, MD "Stressing the Point: Post Traumatic Stress Disorder Claims," For the Defense, 1995

  2. Saul Rosenberg PhD & Mark Levy MD, "Deposing Mental Health Experts on PTSD," Lawyers Guide to Medical Proof, Mathew Bender & Co, April, 2002.

  3. Essentials of Litigating Post Traumatic Stress Disorder Claims (PowerPoint Slide Presentation)

  4. PTSD Links

  5. APA Pamphlet - "Let's Talk Facts About PTSD"

  6. PTSD: Diagnosis & Treatment of Trauma and Stress - Read an Audiograph Booklet and Watch a Multimedia Presentation from Journal of Clinical Psychiatry (up to 2 hours CME credit available) - click to view

  7. Review Article: Psychopharmacologic Treatment of PTSD (Nov-Dec 2002)

  8. also see "PTSD and Brain Imaging" bibliography below

  9. Research: Understanding PTSD Takes On Urgency in Wake of September 11

  10. The Lasting Effects of Psychological Trauma on Memory and the Hippocampus

  11. Relationship of PTSD to Hippocampal Size:

     

    ...personal communication from Michael Weiner, MD, Professor in Residence of Radiology, School of Medicine, University of California, San Francisco

    Relationship of PTSD to Hippocampal Size

    There are at least 5 published studies showing that patients with PTSD have reduced size of the hippocampus.  However, the reductions of hippo volume are only in the order of 5-20%.  Therefore, whenever a group of PTSD subjects is compared to a group of controls, there is a lot of overlap between subjects.

    If any study were to be performed, it would be a MRI and possible a MRS of the hippocampus.  If the patient had reductions at least 1 ( better 2 ) Standard deviation below the mean, this would be consistant with brain injury secondary to PTSD.  But remember,  many PTSD patients have no or only very minor reductions of hippocampal size. For exactly this reason, nobody has suggested that MRI or MRS ( or any other biological test) can be used to diagnose or evaluate severity of PTSD.  Certainly, the VA which pays many millions in compensation for ptsd would be very interested if such a test were available... but none of us have suggested using it.  
     
    Ref. Schuff, N., Marmar, C.R., Weiss, D.S., Neylan, T.C., Schoenfeld, F., Fein, G., and Weiner, M.W.: Reduced hippocampal volume and n-acetylaspartate in post traumatic stress disorder.  In: The Annals of the New York Academy of Sciences. Supplement on Psychobiology of Posttraumatic Stress Disorder 821:516-520, 1997.

    News!  Two interesting articles on the psychopathology of individual differences in susceptibility PTSD may be found at

    IN REVIEW Individual Differences in Posttraumatic Distress: Problems With the DSM-IV Model  

    http://cpa.medical.org/arc/pubs/journal/1999/feb/bowman.htm

    and

    Biological Factors Associated With Susceptibility to Posttraumatic Stress Disorder

    http://cpa.medical.org/arc/pubs/journal/1999/feb/yehuda.htm

    download Acrobat reader

     
    (click to read and for printable pdf version...)

 

 Original PTSD Articles by Mark I. Levy MD, FAPA:

  1. Deposing Mental Health Experts on Post-Traumatic Stress Disorder (PTSD)  Rosenberg, Saul and Levy, Mark, Chapter 716, Lawyers' Guide to Medical Proof, Volume 4 edited by Marshall Houts, J.D., LexisNexis Mathew Bender, 2002
  2. Stressing the Point:When is a Post Traumatic Stress Disorder Claim Legitimate...and When Is It Not?  Mark I. Levy, M.D., F.A.P.A., November 1995 issue of For the Defense, the monthly journal of the Defense Research Institute, Chicago, Illinois.

 

Links to Selected PTSD Bibliography:

  1. PTSD Fact Sheet (pdf file)
  2. PTSD Memory and Brain Effects (pdf file)
  3. PTSD and Domestic Violence (pdf file)
  4. Costs of PTSD (pdf file)
  5. Costs of Workplace Stress (pdf file)

(PTSD and brain imaging)


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A.E. Bennett Research Award. Developmental traumatology. Part II: Brain development [see comments] (De Bellis MD; Biol Psychiatry, 1999 May 15)
Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. (Gurvits TV; Biol Psychiatry, 1996 Dec 1)
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse--a preliminary report. (Bremner JD; Biol Psychiatry, 1997 Jan 1)
Does stress damage the brain? (Bremner JD; Biol Psychiatry, 1999 Apr 1)
MRI reveals gross structural abnormalities in PTSD. (Canive JM; Ann N Y Acad Sci, 1997 Jun 21)
Brain activation in PTSD in response to trauma-related stimuli. (Liberzon I; Biol Psychiatry, 1999 Apr 1)
Structural brain changes in PTSD. Does trauma alter neuroanatomy? (Stein MB; Ann N Y Acad Sci, 1997 Jun 21)
Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. (Bremner JD; Arch Gen Psychiatry, 1997 Mar)
An event-related brain potential investigation of PTSD and PTSD symptoms in abused children. (McPherson WB; Integr Physiol Behav Sci, 1997 Jan-Mar)
Traumatic brain injury and posttraumatic stress disorder: a preliminary investigation of neuropsychological test results in PTSD secondary to motor vehicle accidents. (Hickling EJ; Brain Inj, 1998 Apr)
Relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. (Bryant RA; Am J Psychiatry, 1998 May)
Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. (Shin LM; Am J Psychiatry, 1999 Apr)
Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning. (Yokoyama K; J Physiol Paris, 1998 Jun-Aug)
Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. (Bremner JD; Biol Psychiatry, 1999 Apr 1)
Postconcussive symptoms and posttraumatic stress disorder after mild traumatic brain injury. (Bryant RA; J Nerv Ment Dis, 1999 May)
Findings of mild traumatic brain injury in combat veterans with PTSD and a history of blast concussion. (Trudeau DL; J Neuropsychiatry Clin Neurosci, 1998 Summer)
Classification of veterans with post-traumatic stress disorder using visual brain evoked P3s to traumatic stimuli. (Attias J; Br J Psychiatry, 1996 Jan)
Post-traumatic stress disorder in brain injury patients. (Ohry A; Brain Inj, 1996 Sep)
The influence of traumatic brain injury on acute stress disorder and post-traumatic stress disorder following motor vehicle accidents. (Bryant RA; Brain Inj, 1999 Jan)
Posttraumatic stress symptomatology after childhood traumatic brain injury. (Max JE; J Nerv Ment Dis, 1998 Oct)
Posttraumatic stress disorder in patients with traumatic brain injury and amnesia for the event? (Warden DL; J Neuropsychiatry Clin Neurosci, 1997 Winter)
A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. (Rauch SL; Arch Gen Psychiatry, 1996 May)
Elevated cytotoxicity in combat veterans with long-term post-traumatic stress disorder: preliminary observations. (Laudenslager ML; Brain Behav Immun, 1998 Mar)
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (Lucey JV; Br J Psychiatry, 1997 Oct)
Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack. (Murata K; J Neurol, 1997 Oct)
The psychobiology of posttraumatic stress disorder. (van der Kolk BA; J Clin Psychiatry, 1997)
Serotonergic and noradrenergic markers of post-traumatic stress disorder with and without major depression. (Maes M; Neuropsychopharmacology, 1999 Feb)
Post-traumatic stress disorder following minor and severe closed head injury: 10 single cases. (McMillan TM; Brain Inj, 1996 Oct)
Axis I psychopathology in individuals with traumatic brain injury. (Hibbard MR; J Head Trauma Rehabil, 1998 Aug)
Potential role of the anterior cingulate cortex in PTSD: review and hypothesis. (Hamner MB; Depress Anxiety, 1999)
Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. (Bremner JD; Synapse, 1996 May)
Performance of PTSD patients on standard tests of memory. Implications for trauma. (Wolfe J; Ann N Y Acad Sci, 1997 Jun 21)
What psychological testing and neuroimaging tell us about the treatment of Posttraumatic Stress Disorder by Eye Movement Desensitization and Reprocessing. (Levin P; J Anxiety Disord, 1999 Jan-Apr)
Effect of repeated visual traumatic stimuli on the event related P3 brain potential in post-traumatic stress disorder. (Bleich AV; Int J Neurosci, 1996 Mar)
Neurobehavioural basis for the pharmacotherapy of alcoholism: current and future directions. (Anton RF; Alcohol Alcohol, 1996 Mar)
Cocaine addiction as a neurological disorder: implications for treatment. (Majewska MD; NIDA Res Monogr, 1996)
A positron emission tomographic study of symptom provocation in PTSD. (Shin LM; Ann N Y Acad Sci, 1997 Jun 21)
Electrophysiological abnormalities in PTSD. (Lewine JD; Ann N Y Acad Sci, 1997 Jun 21)
Strain differences in mesotelencephalic dopaminergic neuronal regulation between Fischer 344 and Lewis rats. (Lindley SE; Brain Res, 1999 Jun 19)
Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies. (Bremner JD; Synapse, 1996 May)
Alteration of corticothalamic perfusion ratios during a PTSD flashback. (Liberzon I; Depress Anxiety, 1996-97)
Neural plasticity, neuropeptides and anxiety in animals--implications for understanding and treating affective disorder following traumatic stress in humans. (Adamec R; Neurosci Biobehav Rev, 1998)
Neurobehavioural basis for the pharmacotherapy of alcoholism: current and future directions. (Anton RF; Alcohol Alcohol Suppl, 1996 Mar)
Is posttraumatic stress disorder an overlearned survival response? An evolutionary-learning hypothesis. (Silove D; Psychiatry, 1998 Summer)
Acute stress facilitates long-lasting changes in cholinergic gene expression [see comments] (Kaufer D; Nature, 1998 May 28)
Stressor-induced oscillation. A possible model of the bidirectional symptoms in PTSD. (Antelman SM; Ann N Y Acad Sci, 1997 Jun 21)
Darryl, a cartoon-based measure of cardinal posttraumatic stress symptoms in school-age children. (Neugebauer R; Am J Public Health, 1999 May)
Dissociation between startle and prepulse inhibition in rats exposed to gamma radiation at day 15 of embryogeny. (Mintz M; Brain Res Bull, 1998)
Psychological and physiological responses to stress: the right hemisphere and the hypothalamo-pituitary-adrenal axis, an inquiry into problems of human bonding. (Henry JP; Acta Physiol Scand Suppl, 1997)
The neurobiology of emotionally influenced memory. Implications for understanding traumatic memory. (Cahill L; Ann N Y Acad Sci, 1997 Jun 21)


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For further information, please contact
Mark I. Levy, MD
Tel: 415-388-8040  Fax: 415-388-1225
e-mail: mark@levymd.com

© 2000Mark I. Levy, MD, FAPA